Immunoassay Systems | IDS 主营:Immunoassay Systems | IDS试剂盒授权代理商
服务电话: 4009687988
产品目录
联系我们
产品中心
所在位置:

Rat/Mouse PINP EIA

  • 如果您对该产品感兴趣的话,可以
  • 产品名称:Rat/Mouse PINP EIA
  • 产品型号:AC-33F1
  • 产品展商:其它品牌
  • 产品文档:无相关文档
简单介绍

品名:Rat/Mouse PINP EIA 货号:AC-33F1

产品描述

Code: AC-33F1
Certification:

Research Use Only

Clinical Area: Animal Research
Type: Manual
Format: EIA
RUO/IVD: RUO
Number of Tests: 96 (40 samples in duplicate)
Sample Type: Serum/plasma (Heparin or EDTA), cell culture media
Sample Volume: 5 μL, predilution 1:10
Assay Range: 0.7 – 75 ng/mL

Unique Features

  • Unique – the first commercially available EIA  to quantify type I collagen formation in rat or mouse specimens:
  • Ideal for rodents – only 5μL per well
  • Flexible – serum or plasma samples can be used
  • Fast turnaround time – results in 3 hours
  • Complementary – use in conjunction with IDS RatTRAPTM
  • MouseTRAPTM or RatLapsTM to evaluate both components of bone remodelling
  • A complete assay panel supporting bone research
  • Low sample volume – only 5μL per well
  • Multi-disciplinary use – measuring plasma and serum samples

The Immunodiagnostic Systems Limited Rat/Mouse PINP EIA kit is a competitive enzyme immunoassay (EIA) for the quantitative determination of N-terminal propeptide of type I procollagen (PINP) in rat or mouse serum or plasma samples.

PINP is a particularly useful marker for monitoring the efficacy of osteoporosis therapy with anabolic agents, but it is also one of the best bone turnover markers for monitoring the efficacy of antiresorptive therapy.

The Rat/Mouse PINP EIA assay is a specific method to determine PINP released during rat and mouse bone collagen synthesis, and it has no cross-reactivity for human PINP.

The Rat/Mouse PINP EIA assay can be used for determining the bone formation rate from rat and mouse serum samples1, 2, 3, and from the culture medium in rat and mouse osteoblast cultures.

Previous studies have demonstrated that PINP secretion is increased after stimulation of mouse osteoblasts by BMP-4 and oestrogen in vitro. PINP values are also elevated after treatment with PTH in both young ovariectomised rats and old intact rats.

Rissanen JP et al., Short-term changes in serum PINP predict long-term changes in trabecular bone in the rat ovariectomy model. Calcif Tissue Int. 2008 Feb;82(2):155-61.

Hale LV et al., PINP: a serum biomarker of bone formation in the rat. Bone. 2007 Apr;40(4):1103-9.

Jia T et al., A novel model of adenine-induced tubulointerstitial nephropathy in mice. BMC Nephrol. 2013 May 30;14:116.

Rat-MID™ Osteocalcin EIA

Ratlaps™ (CTX-I) EIA

RatTRAP™ (TRACP 5B) ELISA

MouseTRAP™ (TRACP 5B) ELISA

产品留言
标题
联系人
联系电话
内容
验证码
点击换一张
注:1.可以使用快捷键Alt+S或Ctrl+Enter发送信息!
2.如有必要,请您留下您的详细联系方式!