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25-Hydroxy Vitamin Ds EIA

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  • 产品名称:25-Hydroxy Vitamin Ds EIA
  • 产品型号:AC-57SF1
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简单介绍

品名:25-Hydroxy Vitamin Ds EIA 货号:AC-57SF1

产品描述
Code: AC-57SF1
Certification:

CE Marked
FDA Cleared

Clinical Area: Calcium Metabolism
Type: Manual
Format: EIA
RUO/IVD: IVD
Number of Tests: 96 (40 samples in duplicate)
Sample Type: Serum. EDTA and Heparin Plasma
Sample Volume: 25 μL
Assay Range: 0 - 104 ng/mL (0 to 260 nmol/L)

Unique Features

  • Assure patient results through standardisation to the VDSP ID-LC-MS/MS Reference Method Procedure (RMP)
  • Actionable clinical assessment of vitamin D status provided by measurement of total 25(OH) vitamin D with co-specificity of 25(OH) vitamin D3 and 25(OH) vitamin D2
  • Convenient reagent handling with excellent stability combined with ready to use calibrators and controls
  • Assures accuracy of patient results through standardisation to the VDSP ID-LC-MS/MS Reference Method Procedure (RMP)
  • Reliable test for monitoring vitamin D therapy, regardless of supplementation form
  • Confidence in patient results

The 25-Hydroxy Vitamin DS EIA Assay is intended for the quantitative determination of 25-hydroxyvitamin D [25(OH)D] and other hydroxylated metabolites in human serum and plasma.

Vitamin D is a fat-soluble steroid pro-hormone. Of the two major forms Ergocalciferol (D2) and Cholecalciferol (D3), only vitamin D3 is synthesised by the body.  Main vitamin D sources are: UV exposure from sun which leads to Cholecalciferol production in the upper layers of the skin, foods such as fish, shellfish, mushrooms, vitamin D fortified foods (e.g. milk, juice) and supplements. Approximately 10 – 20 % of vitamin D is supplied through nutritional intake.  Vitamin D is stored in adipose tissue and enters the circulation bound to vitamin D binding protein (VDBP) and albumin.In the liver, vitamin D is hydroxylated to give 25(OH)D which also circulates as a complex with VDBP. A small proportion of the 25(OH)D is further hydroxylated in the kidney, under direct regulation by parathyroid hormone and ionised calcium levels, to form the biologically-active calcitropic hormone 1,25-dihydroxyvitamin D [1,25(OH)2D]. Vitamin D plays a major role in the calcium and phosphorus homeostasis. Vitamin D deficiency is a cause of hyperparathyroidism and diseases related to impaired bone metabolism (e.g. rickets, osteoporosis, and osteomalacia).

Download: CDC Certified Vitamin D Procedures

Sempos C. et al. Vitamin D status as an international issue: National surveys and the problem of standardization. Scand J Clin Lab Invest Suppl. 2012 Apr; 72(Suppl 243):32-40.

Holick, MF., et al. “Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline.” The Journal of Clinical Endocrinology & Metabolism 96.7 (2011): 1911-1930.

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